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pentobarbital will decrease the extent or effect of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel, gated by L-glutamate as well as the glutamatergic agonist kainic acid. L-glutamate functions as an excitator